The Surgeon General’s Call to Action in 2001 sparked widespread public concern about the rising prevalence of obesity and overweight in the United States. Since then, many health funders have supported obesity prevention, healthy eating/active living, and healthy living. Their commitments have ranged in size and scale, from local foundation programs to the Robert Wood Johnson Foundation’s two $500 million national initiatives. Cumulatively, this foundation work has yielded encouraging signs of progress, especially among very young children. Looking ahead, foundations continue to experiment with innovative investments and new strategies, many of which address challenges to moving the work forward.