This webinar explored how cross-sector collaborations among neighborhood organizations, small businesses, and health care systems are driving measurable change to improve health outcomes and expand economic mobility. This session spotlighted a place-based approach anchored in the Memphis Medical District Collaborative, with insights from the Hyde Family Foundation and Methodist Le Bonheur Healthcare. While rooted in Memphis, the strategies highlighted offer practical lessons for communities nationwide. Together, these organizations are investing in neighborhood revitalization, small business development, and health care workforce pipelines to create the conditions for health and economic opportunity for all.