Guided by its mission of “helping people help themselves,” the Claude Worthington Benedum Foundation strategically invests in the creative problem-solving activities of local communities and individuals. For the past decade, the Benedum Foundation has accomplished this mission in its support of a particular health care delivery model: efficient chronic disease management through a medical model leveraging the skills of community health workers in Appalachia. This model provides unique patient care, has shown success for improving the health conditions of a target population, and reduced health care costs—accomplishments that align with the Institute of Health Improvement’s Triple Aim framework.