Early in the COVID-19 pandemic, nearly all states and the federal government approved unprecedented flexibilities that significantly aided the response to the crisis by expanding telehealth, bolstering care in underserved areas, increasing access to mental health services, and importantly, providing some relief for overstressed hospitals and health systems losing health care workers. Now, as temporary waivers in most states are expiring, this publication describes opportunities to apply lessons learned to bring long-term benefits to the health care system.